A simple, selective and rapid reversed phase high performance liquid chromatographic (RPHPLC) method for the analysis of Ciclesonide has been developed and validated. The separation was achieved from HPLC Column (Waters Symmetry C18 5 µ; 4.6 mm x 250 mm) with a mobile phase consisting of 85 volume of Ethanol with 15 volume of Millie-Q-Water at a flow rate of 1.10 ml/min with UV detection at 242 nm. The method is specific and it is observed that no interference with diluents. The proposed method is accurate with 99.6 % recovery for Ciclesonide and precise (% RSD of area of system precision, % RSD of assay of method precision and Intermediate precision are found to be 0.20 %, 0.20 % and 0.20 % respectively). From the linearity study the correlation coefficient is found to be 0.9999, which indicates that the method is linear over 10 % to 150 % range. The method is found robust for possible changes. Therefore, this method can be used as a more convenient and efficient option for the analysis of Ciclesonide to establish the quality of the drug substance during routine analysis with consistent and reproducible results