We introduce a versatile ABC triblock terpoly- mer platform based on poly(ethylene oxide)-block-poly(allyl glycidyl ether)-block-poly(tert-butyl glycidyl ether) (PEO-b-PAGE-b-PtBGE) and subsequent functionalization of the PAGE segment with thiogalactose (hydroxyl), cysteamine (amino), and 2-mercaptopropionic acid (carboxy) by thiol-ene chemistry. These materials are used to prepare core-shell-corona micelles with a PtBGE core, a PAGE shell, and a PEO corona and sizes below 30 nm in aqueous media. We investigate the influence of different functional groups on micelle formation and cellular uptake. Moreover, co-assembly of differently functionalized materials allows to create micelles with a mixed shell and adjustable charge and, in that way, important characteristics such as cell uptake or cytotoxicity can be controlled. Furthermore, we demonstrate that even the uptake mechanism depends on the substitution pattern of the underlying triblock terpolymer.

No abstract

No abstract

Wie das letzte Jahr zeigte, ist die Forschung über Polymere und ihre Aggregate wichtig, um die Coronapandemie einzudämmen. Darüber hinaus gab es in der makromolekularen Forschung eine Vielzahl an Neuerungen und wegweisende Entwicklungen, etwa bei Materialien und polymerbasierter Elektronik. Dieser Trendbericht umfasst nicht nur Highlights, sondern präsentiert auch die Forschungsinteressen des akademischen Nachwuchses.