Introduction: The term abortion has been derived from the Latin word "ABORIRI" which means to detach from its proper place. "ab" means abnormal and it indicates premature expulsion. "ORIRI" means to be born or to arise. Aim of the present study was to evaluate the role of combination of Mifepristone and Misoprostol in pregnancy termination up to 63 days. Safety, efficacy, cost effectiveness and complications have been evaluated. Material and Methods: This study was carried out at Rajendra Institute of Medical Sciences, Ranchi in the department of Obstetrics & Gynaecology from June 2016 to Oct 2017. 200 cases were selected from outpatient department and labour room of Obstetrics & Gynaecology. Result: In my study 93% of women had successful abortion and 7% had to undergo surgical evacuation. It was observed that majority 98% of the cases were between 21-30 years of age and most of them 56.5% came from urban areas. 65.5% of the cases belonged to literate groups. In majority of the cases 76.5% the indication for pregnancy termination was unwanted pregnancy followed by contraceptive failure. 18.5% of the cases were primigravida and 56% of the cases were gravida two. Conclusion: Unrestricted use and over the counter purchase of drugs for medical abortion is detrimental for maternal health. Proper dosing, timing, route and counseling by the medical professionals can prevent serious complications.