BackgroundSubstance use is generally initiated in adolescence or early adulthood and is commonly associated with several physical, psychological, emotional and social problems. The objective of this study is to assess the age of onset of substance use differences on psychosocial problems among individuals with substance use disorders (SUDs) residing in drug rehabilitation centers.MethodsA descriptive cross sectional research design was carried out. Probability Proportional to Size (PPS) sampling technique was used to select the drug rehabilitation centers and all the respondents meeting the inclusion criteria of the selected seven rehabilitation centers were taken as a sample and comprised of 221 diagnosed individuals with SUDs. A semi structured self administered questionnaires were used to collect the information regarding demographic and substance use related characteristics. A standard tool Drug Use Screening Inventory-Revised (DUSI-R) was used to assess the psychosocial problems among individuals with SUDs. Data were analyzed using both descriptive and inferential statistics. Multivariate general linear model (MANOVA and MANCOVA) was used to evaluate differences in psychosocial problems between early vs late onset substance users.ResultThe age of onset of substance use was significantly associated with psychosocial problems. The mean psychosocial problem scores were higher in early onset substance user (17 years or younger) than late onset substance user (18 years or higher) in various domains of DUSI-R even after controlling confounding factors. The two groups (early vs late) differed significantly in relation to age, gender, occupational status, current types of substance use, frequency of use, mode of substance use and relapse history.ConclusionThe study indicated that early onset substance users are at higher risk for psychosocial problems in various areas of life such as Behavior Pattern, Psychiatric disorder, Family system, Peer relationship, Leisure/Recreation and Work adjustment compared to late onset substance users. It highlights the need for early prevention, screening, and timely intervention among those individuals.

Background: Adolescence is characterized by unique, multiple physical, psychological and social development. Understanding the well-being of adolescents and the factors that contribute to it will help towards clarifying and defining ways to better help adolescents prepare for adult life. Therefore, the present study aims to find out the relationship between Perceived Social Support (PSS) and Psychological Well-Being (PWB) among Nepalese adolescence based on mediating role of Self-esteem (SE). Methods: The study was conducted among 348 adolescents studying in grade 9 and 10 of government secondary level schools of Pokhara Metropolitan city, Nepal. Data were collected through self-administered standard tools-Multidimensional Scale of Perceived Social Support (MSPSS), Rosenberg self-esteem scale (RSES) and General Health Questionnaire (GHQ-12). For statistical analysis descriptive statistics, correlation, regression and mediation analyses were used. The statistical significance of mediating effect of the tested model was examined through a path proposed by Baron and Kenny and Bootstrap method. Results: Overall, the finding suggests that PSS indirectly affects PWB of adolescents through mediating variable SE. Adolescents who perceive good social support had higher SE, which in turn contributed to their PWB. Furthermore, the study found no significant gender difference for PSS, SE and PWB. Also among various sources of PSS, both boys and girls were more oriented towards family for social support than friends and others. Conclusion: Adolescents who experience higher social support are likely to have higher SE and are more likely to have better PWB. The findings of the study will be useful to the parents, teachers, counselors, psychologist and researchers to develop strategies to enhance adolescent's mental health.

Summary Biological invasion is increasing worldwide and the management of invasive species is becoming an important priority for vegetation managers. Success of invasive species management depends on a thorough understanding of the biology of the organism in question and the effectiveness of current management efforts, in order to identify the best practices for management improvement. In this review, we synthesised current biological knowledge of a noxious invasive weed Ageratina adenophora to identify knowledge gaps and assessed management efforts to identify best practices. Finally, we proposed some priority areas for future research to fill knowledge gaps and improve management. Our analysis showed that A. adenophora has already invaded 40 countries, mainly in Asia, Oceania, Africa and Europe. Phenotypic plasticity, allelopathic interference and invasion‐mediated changes in the soil microbial community are the proposed mechanisms that facilitate rapid spread of this weed. However, allelopathy as a mechanism of invasion success of this weed has not been supported by ecologically meaningful experiments. Though mechanical, chemical and biological control measures have been used, their success remains limited and the weed continues to spread in new regions. Among seven biological control agents examined to date, gall fly (Procecidochares utilis) and leaf spot fungus (Passalora ageratinae) have been effective in limited areas to suppress growth of this weed. Some perennial native grasses (e.g. Setaria sphacellata and Lolium perenne) have shown potential to competitively suppress A. adenophora. In conclusion, understanding the invasion mechanisms, exploring further to identify effective biological control agents, combined with approaches of ecological restoration, could help in the management of this weed.

Background Non-suicidal self-injury (NSSI) and suicidal behavior (SB) are the major public health problems in adolescents. Despite the increased focus on these phenomena, there exist no reliable data in Nepal. This study aimed to determine the prevalence of NSSI and SB among adolescents. Furthermore the study identified the relationship between these two behaviors and assessed demographic, behavioral, and psychological risk factors of NSSI and SB in Nepalese adolescents in a representative sample of the general population. Methods The study was conducted among 730 adolescents studying in grade 9 to 12 of public and private schools of Pokhara Metropolitan city, Nepal. Data were collected through self administered standard tools- Functional Assessment of Self Mutilation (FASM) tool, Suicidal Behaviors Questionnaire-Revised (SBQ-R), Rosenberg self-esteem scale (RSES) and Beck Depression Inventory (BDI). Descriptive statistical measures such as frequency, percentage, mean, standard deviation, range were used to assess demographic characteristics and adolescent’s behavior regarding NSSI and suicide. For inferential analysis chi-square and one way ANOVA test was used. Furthermore, to determine the predictors of NSSI and SB, multiple logistic regression analysis was used. Results Regarding behavioral characteristics, nearly half of the sample 327 (44.8%) reported a history of NSSI in past 1 year. Furthermore, 25.8% (n = 188) of the overall sample engaged in minor NSSI only and 3.42% (n = 25) engaged in at least one act of moderate/severe NSSI. The mean number of type of NSSI performed was 2.63 ± 1.71. The most common type of NSSI method used were picking at wound (27.3%), biting self (20.3%), pulling hair out (11.8%), cutting self (11.1%). Boys (52.6%) were more likely to be engaged in NSSI than girls (47.4%) (χ2  =  10.298, p  =  0.002). Furthermore, among 730 adolescents who completed the SBQ-R questionnaire, 131 (17.9%) had suicidal behaviors (SB) (as defined by SBQ-R a total score ≥ 7). Regarding sex differences female were significantly higher in life time prevalence of suicidal behavior than male (χ2 = 30.26, p = 0.001). Simple Chi-square tests indicated that NSSI was significantly associated with SB (χ2 = 58.16, P < .001). Logistic regressions identified the four significant predictors of NSSI behavior: male, low-level of self-esteem (SE), moderate to severe form of depression and SB. Similarly, significant predictors of SB were: female, low-level of SE, moderate to severe form of depression and NSSI behavior. Conclusion The prevalence of both NSSI and SB is high in adolescents. Despite the differences between NSSI and SB a significant number of adolescents reported a history of both behaviors. Lower level of SE and moderate to severe depression were the significant predictors of both NSSI and SB. Furthermore, male and adolescents with the history of SB were at risk of NSSI behavior whereas female sex and adolescents with the history of NSSI were at risk of SB.

Background: Ostomy changes the overall lifestyle of a person, and ostomates have been identified as a chronic illness population frequently experiencing adjustment problems. Purpose: The aim of this study was to determine the psychosocial adjustment and its predictors among patients with ostomy in Nepal. Patients and methods:A descriptive cross-sectional study was conducted in two stoma clinics of Nepal. Patients who had a colostomy, ileostomy, or urostomy, visited the selected stoma clinics during the data collection period, and who had ostomy for at least 6 months before data collection were included in the study. A total of 130 patients were included in this study. Data on sociodemographic and clinical variables were collected. Psychosocial adjustment score was measured using Ostomy Adjustment Inventory-23. Results: A total of 130 patients (80 males and 50 females) were included in the study. The mean age of the patients was 51 years, ranging from 23 to 78 years. The study findings revealed that mean ±SD adjustment score was 41.49±13.57, indicating moderate impairment in the psychosocial adjustment among ostomates, and the mean ±SD scores of acceptance, anxious preoccupation, social engagement, and anger were 22. Perceived lack of family support (b=−0.367, P<0.001), total dependence on others to care for ostomy (b=−0.357, P<0.001), and unemployment (b=−0.144, P=0.032) significantly predicted lower psychosocial adjustment scores. However, increased time since ostomy surgery (b=0.361, P<0.001) significantly predicted higher psychosocial adjustment scores. Conclusion:Ostomy often affects all aspects of a patient's life; however, emotional, sexual, and social lives are the most affected areas. Importantly, the focus of treatment for ostomates should expand beyond the physical boundaries and should consider psychosocial concerns as well.