The synthesis of various 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones was realized following a simple three-step process. The protocol utilized the photodecarboxylative addition of readily available carboxylates to N-(bromoalkyl)phthalimides as a versatile and efficient key step. The initially obtained hydroxyphthalimidines were readily converted to the desired N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones via acid-catalyzed dehydration and subsequent nucleophilic substitution with the corresponding secondary amines. The procedure was successfully applied to the synthesis of known local anesthetics (AL-12, AL-12B and AL-5) in their neutral forms.

Today, more than 70 million tons of lignin are produced by the pulp and paper industry 11 every year. However, the utilization of lignin as a source for chemical synthesis is still limited due 12 to the complex and heterogeneous lignin structure. The purpose of this study was a selective 13 photodegradation of industrially available kraft lignin in order to obtain appropriate fragments

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