No abstract

Conjugate Addition of Curcumins to Chalcones and Azodicarboxylates. -A one-pot cascade double Michael reaction of curcumin with chalcones proceeds with good diastereoselectivity to give highly substituted cyclohexanones (III) and (V). Azodicarboxylates react under mild conditions to afford Michael adducts (VIII) stopped at the single addition stage. -(AYYAGARI, N.; MEHTA, A.; GOPI, E.; DEB, I.; MOBIN, S. M.; NAMBOOTHIRI*, I. N. N.; Tetrahedron 69 (2013) 29, 5973-5980, http://dx.

Successive reaction of the chalcones (I) with the ester (II) and hydrazine hydrate (III) yields tautomeric mixtures which can be separated.