Santonin, a natural product, was
aromatized with molecular iodine
as the catalyst. The new compound was characterized as (S)-methyl-2-(7-hydroxy-5,8-dimethylnaphthalen-2-yl) propanoate (2) based on 2D NMR spectroscopic data. Structurally, compound 2 was highly similar to the anti-inflammatory drug naproxen.
The new naproxen analogue had significant potency against cyclooxygenase
1 and 2 (IC50 = 31.0 and 66.1 μM, respectively).
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