The effect of impurity (sodium sulfate Na2SO4; copper sulfate CuSO4; potassium ferrocyanide K4Fe(CN)6; and triammonium citrate (NH4)3C6H5O7) concentration on the positive matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) spectra of insulin is described. 2,5-Dihydroxybenzoic acid was used as a desorption matrix. The estimated maximum concentrations of tested salts for which no insulin signal was observed were determined.
Some aspects of the matrix-assisted laser desorption/ionization (MALDI) method in the analysis of hemoglobin from whole human blood are described. These aspects are: sensitivity of this method, fragmentation of hemoglobin ions, and influence of some impurities (sodium chloride NaCl, sodium sulfate Na2SO4, and potassium ferrocyanide K4Fe(CN)6) on the detection process. As a matrix, alpha-cyano-4-hydroxycinnamic acid (CCA) was used. The estimated maximum concentrations of tested salts for which no hemoglobin signal was observed were determined.
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