Diabetes Mellitus is a disease characterized by hyperglycemia resulting from defects in insulin secretion. Garcinia Cambogia is an Asian plant used commonly as nutritional supplement for weight loss.Objective: The purpose of this study is to perform a mini review about Garcinia Cambogia consumption and its relationship with DM condition in humans.Methods: Studies were searched in Pubmed, Web of Science and Scopus databases and 62 articles were identified and reviewed in an integrative method. After a criterial analysis, 3 articles were included on this mini review.Results: Two studies found that Garcinia Cambogia in association with Glucomannan had a positive association related to comorbidities as Diabetes Mellitus and its markers (glycemia, triglycerides, cholesterol). However, a case report showed an adverse effect on a high dose Garcinia Cambogia consumption. Conclusion:It is possible that Garcinia Cambogia consumption influences Diabetes Mellitus condition, although more studies are necessary for higher efficacy understanding.

Olive oil has phenolic compounds, such as hydroxytyrosol, tyrosol e oleuropein. Through this rich composition, olive oil conditions its biological actions to neuroprotection, such reactive oxygen species, antioxidant and anti-inflammatory action, inhibition of lipid peroxidation, restoration of glutathione and anti-apoptotic properties.Objective: Conduct an integrative mini literature review with the beneficial properties of extra virgin olive oil and its polyphenols for possible prevention of Parkinson's disease.Method: To identify potentially relevant studies for the present mini-review, a search of the literature in databases (PubMed, Scopus and Web Of Science) was conducted during April 2021. The term "extra virgin Olive oil" was searched in combination with "Parkinson". The terms were searched in the title, abstract and keyword. No restrictions were applied as to the language or date of publication. Results and discussion:The sample consisted of 6 articles. When listing the articles found, beneficial effects of polyphenols in olive oil were evidenced, against brain oxidative damage caused by some toxins, in addition to triggering an autophagic response and interfering with the cell signaling pathways and mechanisms associated with cell function, survival or death. Conclusion:The beneficial effects of olive oil and its polyphenols in Parkinson's disease have been extensively researched and associated with the modulation of many cell pathways. Its ability to increase the antioxidant system and reduce inflammation has been linked to the protective effect in Parkinson's disease. Polyphenols have antioxidant power in vitro, studies in cell cultures; therefore, further in vivo studies are needed to confirm the protective effects of olive oil and its polyphenols on Parkinson's disease, in order to identify biologically relevant concentrations for therapeutic purposes.

Objective: The aim of this study was to evaluate the influence of early exposure to agricultural pesticides and their relationship with autism spectrum disorder. Data source: This systematic review was registered at PROSPERO as CRD42020204842. The subject was systematically analyzed on PubMed, Scopus, and Web of Science databases until April 2021. Only studies with humans with early exposure to agricultural pesticides and diagnosis of autism were included. Exclusion criteria were studies on pesticides for domestic or veterinary use and late exposure. There were no language and time restriction. The quality analysis of the studies used the Newcastle-Ottawa Scale. Data synthesis: Six case-control studies were included; three of them measured the route of exposure by maternal biomarkers and the others by the residence address. The studies had scores between moderate and high in the quality assessment tool. It was found high rates of association between early exposure to agricultural pesticides and autism and detection limit above the quantification for a sample of polychlorinated biphenyls, hexachlorobenzene, and dichlorodiphenyldichloroethylene. Conclusions: There is evidence concerning the exposure to agricultural pesticides in early life and the development of the autism spectrum disorder; however, more studies are required to better understand their possible association.

ABSTRACT Introduction and Objectives: Ultra-processed foods are determined by the level of processing. There has been a relationship between their consumption and several risk factors for diseases related to these foods, such as cardiovascular disease. These factors can corroborate the illness and increase the risk of mortality of the adult population. The objective of this systematic review was to verify the contribution of the consumption of ultra-processed foods to the risk of mortality. Methods: Through PubMed, Scopus and Web of Science, scientific databases, studies that examine the relationship between the consumption of ultra-processed foods and the risk of mortality up to February 2021 were systematically researched. Results and Conclusion: Evidence analysis was performed using robust tools to assess the risk of bias and methodological quality. A total of five studies were included. The consumption of ultra-processed foods was associated with a higher risk of mortality from all causes, proportional to their consumption (in the largest quartiles of consumption, greater risks were found).