In the course of our research we have developed a technology for fabricating an osteoplastic material from natural bone tissue. The obtained preparation in the form of gel contains hydroxyapatite, calcium triphosphate compounds and stimulators for regeneration. The proposed experimental material produces a stimulating effect on the growth of animal cell types; it enables to produce bioactive materials with increased biocompatibility. Application of the experimental gel facilitates the process of bone-tissue regeneration in the laboratory animals, which, in its turn, confirms the optimal composition of the material. We have established that during the integration of our osteoinductive material the defect zone is completely replaced by the bone tissue.

In the course of this study we established that the laboratory sample in granulated form developed by us has a stimulating effect on the growth and proliferation of osteoblasts. Analysis of the data (CT, MRI) of the biological material obtained from the animals withdrawn from the experiment showed a statistically significant replacement of the artificial defect with bone tissue with signs of restoration of the cortical plate. The analysis of the CT results indicates that this method is sufficiently informative in assessing the regeneration of the trabecular structure of bone tissue. The study (MRI) of the bone material obtained from the animals participating in the experiment showed that when the osteoinductive material was integrated, the defect zone was replaced by 90%. In the projection of the defect, the newly formed tissue of a homogeneous structure was determined, corresponding in density to bone tissue with a high degree of mineralization. There was a complete restoration of bone tissue in the projection of the defect.

In the course of this study, it was found that currently more than 30 million people are forced to take non-steroidal anti-inflammatory drugs (NSAIDs) daily. It is reliably known that nonsteroidal anti-inflammatory drugs with prolonged use cause a number of side effects, the main of which are erosive and ulcerative changes in the mucous membrane of the gastrointestinal tract. Special attention is paid to the classification and comparative evaluation of various NSAIDs and possible complications in the case of their use. As a result of the performed analysis, it was found that rectal forms have been developed for most NSAIDs, which is convenient for use in pediatric practice, in patients with gastropathies, nausea, vomiting, swallowing disorders, in an unconscious state. The common sides of their pharmacological action are anti-inflammatory, antipyretic, analgesic effects due to inhibition of cyclooxygenase I, II activity and leading to disruption of arachidonic acid metabolism with suppression of prostaglandin synthesis in the focus of inflammation. Data analysis showed that NSAID suppositories are prescribed for: articular syndrome; pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and musculoskeletal system; rheumatism, diffuse connective tissue diseases; dysmenorrhea.