During the last several years researches have been carried out in order to study the possibility of autofluorescence diagnostics application in dentistry for caries and different periodontium tissues diseases diagnostics. We carried out the research of periodontium tissues autofluorescence images and spectra to develop the method of autofluorescence diagnostics of premorbid conditions of inflammatory periodontium tissues diseases.

This paper deals with the possibility of application of aluminum phthalocyanine (AlPc) nanoparticles in clinical practice. AlPc fluoresces in the molecular form but in the form of nanoparticles it does not. Separation of molecules from an AlPc nanoparticle and therefore the appearance of fluorescence occurs under the effect of a number of biochemo‐physical factors. Owing to this feature the application of AlPc nanoparticles followed by the measurement of fluorescence spectra is proposed as a diagnostics method. It was shown that after AlPc nanoparticle application on a tooth surface the fluorescence intensity in the enamel microdamage area is 2–3 times higher than that in the normal enamel area. The appearance of fluorescence after application of AlPc nanoparticles on skin autografts testifies to the presence of inflammation. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

It wasfound that irradiation of aqueous solution of aluminium sulphophthalocyanine (SPcAl) by light with wavelength of 805 nm in the presence of sodium ascorbate results in photodynamic type I effect. S2PcA1 in adsorbed state on proteins or polysaccharide structures was shown to possess rather intense long wavelength absorption band in the NIR spectral region. The comparative tests of SPcAl with sodium ascorbate on mice with Ehrlich carcinoma and leucosis P-388 showed that photodynamic efficiency in the case of NIR irradiation (790 nm) is not lower than using visible irradiation (675 nm).

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