The objective of the study was to evaluate efficacy and safety of ixekizumab in psoriasis patients under clinical practice conditions. Observational, retrospective, multicentre study that included patients with ixekizumab from March 2017 to March 2019. ≥ 90% reduction in the Psoriasis Area and Severity Index (PASI 90) and absolute PASI <2 were the parameters used to assess treatment response. Adverse events (AEs) were collected. Of the 301 patients included, 111 were women (36.9%), mean age was 48.5 (±13.5) years. Mean baseline PASI score was 13.5 (±7.7). More than half of the patients (68.5%) had received at least one biological drug before. At 3 months, 208 (76.5%) patients achieved PASI <2 and 156 (57.3%) PASI 90. At 12 months, 130 (73.4%) patients achieved absolute PASI <2 and 104 (58.7%) PASI 90. Multivariate analysis revealed that prior use of biologics was influential in achieving PASI <2 at both 3 and 12 months (OR 2.82, P = .006; OR 9.51, P < .001, respectively). Sixty-five patients (21.59%) exhibited at least one AE, injection site reaction was the most

Photoallergic contact dermatitis (PACD) is a delayed-type reaction that occurs when an exogenous agent contacts the skin, which is then exposed to ultraviolet (UV) and/or visible radiation. 1 We herein present the first case of PACD caused by benzophenone in swimming goggles. CASE REPORTA 66-year-old man developed a red periorbital pruritic rash that began 12 hours after wearing his new Arena Orbit 2 swimming goggles in an outdoor pool. He presented with eyelid, periorbital, and scalp erythema as well as vesicles and edema (Figure 1). We performed a patch test with the Spanish baseline series, rubber and plastics/glues series (Martitor, Barcelona, Spain), and two pieces of rubber from the eye and the scalp zones of the goggles "as is". Test series were applied on the back under occlusion for 48 hours in Curatest and readings were performed on day (D) 2, D4, and D8. Positive reactions were found to quaternium-15 1% pet. (D2, D4, and D8++), p-tert-butylphenol formaldehyde resin 1% pet. (D8++), and benzoyl peroxide 1% pet. (D4 and D8+) F I G U R E 1 Acute eczematous reaction in the area where the swimming goggles were in skin contact following sun exposure MELÉ-NINOT ET AL. 59

Subungual squamous cell carcinoma is very rare, but it is the most frequent primary malignant tumor of the nail bed. Therefore, its diagnosis and treatment are crucial to ensure a favorable prognosis. We present the sonographic findings in a case of a subungual squamous cell carcinoma. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 46:212-214, 2018.

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