It was found that the main mechanisms of action of 4-hydroxyphenylpyruvatedioxygenase inhibitors are the development of tyrosinemia and alternations in thyroid hormone level as a result of hepatic enzyme induction. The main target organs of its action are the eyes, liver and thyroid gland. It was proved that the most adequate model for extrapolation of the effects of tyrosinemia on humans are mice, because their tyrosine aminotransferase activity level is similar to that in humans.

The aim: Evaluation of the influence of plant protection chemicals on the fatty acid composition of sunflower seeds. Materials and methods: Study of the effects of pesticides, study of the effects of pesticides on the fatty acid composition (lipid) of sunflower seed by gas-liquid chromatography was studied. Results: It was found that the content of oleic and linoleic unsaturated fatty acids did not differ significantly from the control. The content of linolenic and arachidonic acids was at the level of the control group. A similar pattern was observed in relation to the content of saturated fatty acids, in particular myristic, pentodecanoic, palmitic, margaric, stearic. The total content of fatty acids (unsaturated fatty acids and saturated fatty) selected under different seed protection schemes did not differ significantly from control. Conclusions: It is proved that the application of the investigated pesticides in various schemes of chemical protection of sunflower crops does not affect the nutritional and biological value of the seeds.

Blood pressure is one of the critical indicators of a person's physiological state. This indicator and the pulse reflect the state of the cardiovascular system. Their values can directly or indirectly determine the presence of diseases of the heart and blood vessels, and other organs. Therefore, determination of blood pressure among people of different levels of health is an urgent task of modern medicine. The aim of the work: hygienic assessment and monitoring of blood pressure in medical students smoking e-cigarettes. Materials and methods: Quantitative and qualitative analysis of the level of systolic, diastolic pressure, mean arterial and pulse pressure in medical students aged 18-23 years, before and after smoking e-cigarettes was carried out. Results: The findings of the study fully reflect the importance of tonometry. Thus, the level of systolic blood pressure increased after 10 minutes by an average of 7.7%, but after 50 minutes returned to optimal value. The level of diastolic blood pressure increased after 10 minutes by an average of 8.8%, but after 50 minutes – an increase of 4%. Conclusions: This type of changes in the short period are not critical, as the body’ compensatory mechanisms stabilize hemodynamic parameters, but daily smoking can lead to the development of COPD, as well as pathology of the cardiovascular system, including myocardial ischemia or heart failure. Therefore, smoking e-cigarettes cannot be attributed to a harmless type of habit.

The aim: To detect the main problems regarding available high-quality stomatological service in Ukraine and define their main solutions. Materials and methods: The authors used general scientific methods of synthesis, generalization, scientific data interpreting, systemic approach method, medical statistic method, and analysis of the activity of state and private institutions dealing with stomatological service in Ukraine. The paper is based on the materials of a representative selective study of Ukrainian households, held by the State Committee of Statistics of Ukraine to study people’s self-estimation of their health and the availability of certain medical services. Results: Most citizens of Ukraine (60-80%) are treated in the state/public healthcare sector. Though, during the last century, a decrease in dental visits per citizen in the state and public institutions has been noted, as well as a decrease of all medical service types’ volume, offered in the mentioned institutions. In Ukraine the observed trends are represented as the decrease in the network institutions number, insufficient budgeting of state/public medical institutions, prevailing commercial characteristics of stomatological service and people’s low income, which leads to decreased affordability, and quality of medical service, thus negatively affecting people’s health. Conclusions: The fundamental studies of the quality assessment show that the medical service requires strong structure, process quality, and result quality. The quality of medical service organization is extremely important and it should be maintained high on all levels of management and treatment processes, regarding the conditions of medical process and resources of medical organizations. Medical service should be patient-centered. To solve the problem, the entire state system of quality management is required in Ukraine.

The aim: Hazard characterization and assessment of combined exposure to several pesticides when they simultaneously get to the human body with bakery products. Materials and methods: Methods of analytical analysis of the range of pesticide active substances, which are registered and used in modern systems of grain crop protection in Ukraine, were used in the study. Normative documents of national legislation on hygienic regulation of pesticides and methodological approaches to assessing the combined e!ects of pesticide mixtures in food products serve as materials for assessment. Results: It is established that the total risk of exposure to residual amounts of pesticides in bread products (wheat and rye bread) during its comparable getting into the body was 0.59 for children 2-6 years and 0.36 - for adults, with an allowable value of ≤ 1.0. The combined e!ect of pesticides per unit of children’s body weight is higher, but also lies within acceptable limits. The largest contribution to the overall risk of combined exposure to triazoles is made by flutriafol (38.5-47.0%), which in the future may be the basis for substantiating measures to reduce such exposure and make appropriate management decisions. Conclusions: Safety of consumption of agricultural products is ensured by strict following hygienic regulations for the pesticide application (application rates, frequency of treatments, pre-harvest intervals), which makes it impossible to accumulate their residual amounts in food. Triazole pesticides, widely used in almost all crop protection systems, pose a potential risk of adverse health e!ects due to additive or synergistic effects.