Relevance. Against the background of stress and high physiological load, cows experience a lack of energy, the need for which increases many times over in comparison with the dry period, in connection with this, their body is forced to use the reserves of adipose tissue. It is important to timely prevent and monitor the status of cows during the transition period.Methods. The methodology of the work was to study the effectiveness of the use of immunostimulating drugs PS-2, Prevention-N-E and PDE + E-selen. For scientific research, 4 groups of down-calving cows of the Holsteinized Black-and-White breed were selected, 10 animals each. Dry cows of the 1st and 2nd experimental groups received PS-2 and Prevention-N-E intramuscularly at a dose of 10.0 ml three times (40, 20 and 10 days before calving), animals of the 3rd experimental group were injected subcutaneously with tissue preparation PDE (denatured emulsified placenta) at a dose of 20.0 ml and intramuscularly — with a complex mineral and vitamin preparation E-selen at a dose of 10.0 ml 20 days before calving. Biological preparations were not used in animals of the control group.Results. An analysis was made of the prevalence of postpartum metabolic disorders: clinically pronounced hypocalcemia was observed in 5.9% of the newly-calved cows, ketosis — in 11.6%, subclinical hypocalcemia — in 17.7%, and a latent form of ketosis — in 22.7%. Biological preparations PS-2 and Prevention-N-E have a corrective effect on the synthesis of aminotransferases, mineral and carbohydrate metabolism, digestibility of macronutrients, against which background the number of newly-calved cows with subclinical forms of ketosis and hypocalcemia is reduced by 2 times.

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The aim of the research was to determine the feasibility of using immunostimulants in the prevention and treatment of cows՚ mastitis. The work was carried out using biopreparations developed by the scientists of the Chuvash State Agrarian University: Prevention-N-E and Prevention-N-B-S, as well as a homeopathic medicine for the treatment of mastitis Mastinol. Prevention-N-B-S showed the greatest preventive effect, however, this difference with Prevention-N-E was insignificant (P>0.05). It is noteworthy that only in the 2nd experimental group, where Prevention-N-B-S was used, cows with clinical mastitis were not detected both before and after calving. Treatment of cows whose mastitis prevention using immunostimulants proved ineffective was carried out in the 1st and 3rd experimental groups. Thus, the therapy of cows with mastitis showed that the recovery of the cow of the 1st experimental group, which were treated with Prevention-Nth, recovered after 4±0.08 days, which is 7±0.52 days less than in the 3rd experimental group, where Mastinol was used. Atrophy of the udder lobe was observed in one cow in the 3rd experimental group. It was found that the treatment of cows՚ mastitis with Prevention-N-E biopreparation was more effective than the homeopathic preparation Mastinol. The results of this study have shown that the use of immunostimulants in the prevention and treatment of cows՚ mastitis is advisable. Thus, in the prevention of cow mastitis, Prevention-N-B-S demonstrated the most pronounced corresponding effect from among the tested biopreparations, and in the treatment of mastitis – Prevention-N-E.

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Currently, animal husbandry is rapidly developing, which often has an adverse effect on animals, violating immunity and reducing the natural resistance of the body. Therefore, cows with high milk productivity are most susceptible to various inflammatory processes, including mastitis. The purpose of this work was the scientific and practical justification of the feasibility of using immunotropic agents of a new generation for the prevention and treatment of cow mastitis. In the first series of experiments, prevention of cow mastitis was carried out with immunotropic drugs Prevention- N-A-M and Prevention-N-B-S, developed by scientists of the Chuvash State Agrarian University, as well as with the drug Mastinol; in the second series of experiments – treatment with drugs Prevention-N-A-M, Prevention-N-B-S, amoxicillin. It has been established that immunotropic drugs contribute to the prevention and treatment of cow mastitis, improve the function of hematopoiesis, metabolism, activate factors of cellular and humoral resistance, reproductive and productive qualities of the body, with a more pronounced Prevention-N-A-M effect.