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Monascus sp. is a mold that is used for rice fermentation so that the brown rice is produced (Red Mold Rice) or Angkak. This rice has long been used on Asian food and traditional medicine. Angkak contains many bioactive compounds, including monakolin which is potentially to be used as nutraceutical. Monascus sp. produced pigments include yellow (Ankaflavin, Monaskin), Orange (Rubropunktatin, Monaskorubrin) and Red (Rubropunktamin, monaskorubramin) which have various biological activities. The purpose of the study was to know the pigments of the Monascus sp. as a compound antidiabetic candidate. This includes the Azaphilone Kapang Monascus sp. derivative compound In Silico. The test compound consists of 57 compounds of Monascus sp. Glycogen Fosforilase used as an antidiabetic receptor. Ligan preparation is drawn using ChemDraw software then with Marvin Sketch done Protonasi. Testing Drug Scan (Screening ligand based Drug likeness). The preparation of receptors by downloading antidiabetic receptors in Protein Data Bank (GDP). The ADME study was conducted with PreADMET web-based software. Validate the docking method and molecular tethering using the Autodock software 4.2.6. Drugscan test results on compounds Isolate MPs4 have qualified grades in all parameters such as molecular weight, proton donor, proton acceptor, log p and molar refractory. The results of the ADME test in the compound Isolate MPs4 have a qualified value in all parameters Caco-2, HIA (Human Intestinal Absorption), as well as in the PPB (Protein Plasma Binding). The result of the docking test in the Isolate compound MPs4 to be the best and qualified compound because it has a smaller affinity binding than the natural ligands and the comparator ligand (glibenclamide). The result of this research Isolate MPs4 is the candidate for new drugs antidiabetic. Keyword : Monascus sp., In silico, Azaphilone, Docking, Antidiabetic

ABSTRAK Dengan meningkatkan kasus covid-19 yang terjadi di dunia dan khususnya di Indonesia serta munculnya konsep new normal, maka perlu langkah-langkah untuk antisipasi mengurangi penyebaran covid-19 di era new normal ini. Sehingga Prodi Farmasi STIKes Bakti Tunas Husada telah melakukan beberapa kegiatan pengabdian masyarakat di Kota Tasikmalaya tentang penyuluhan proteksi diri di era new normal dan workshop pembuatan sediaan herbal sebagai imunomodulator. Metode yang digunakan dalam kegiatan pengabdian masyarakat adalah ceramah, diskusi dan workshop. Peserta kegiatan ini adalah kader-kader kecamatan dan Penanggung jawab kesehatan tradisional di tiap puskesmas Kota Tasikmalaya. Dari kegiatan pengabdian yang dilakukan dapat berjalan dengan lancar dan sukses serta peserta dapat memahami materi yang disampaikan. Keyword: covid-19, new normal, proteksi diri, imunomodulator  ABSTRACT By increasing cases of Covid-19 that have occurred in the world and especially in Indonesia and the emergence of the new normal concept, steps are needed to anticipate reducing the spread of Covid-19 in this new normal era. So that the Pharmacy Program at STIKes Bakti Tunas Husada has carried out several community service activities in the Tasikmalaya City regarding self-protection counseling in the new normal era and workshops on making herbal preparations as immunomodulators. The methods used in community service activities are lectures, discussions, and workshops. Participants in this activity are sub-district cadres and people in charge of the traditional health of each puskesmas at Tasikmalaya City. The service activities carried out can run smoothly and successfully and participants can understand the material presented. Keywords: covid-19, new normal, immunomodulator, self-protection