Przegląd Dermatologiczny 2016/4 330 StreSzczenie Rogowacenie słoneczne (ang. actinic keratosis -AK) to jednostka chorobowa, która charakteryzuje się występowaniem zmian hiperkeratotycznych na skórze uszkodzonej przez promieniowanie ultrafioletowe. Zmiany te mogą ulec progresji do raka kolczysto-lub podstawnokomór-kowego. Obecnie w leczeniu AK wykorzystuje się zarówno farmakoterapię, jak i metody zabiegowe. Do najczęściej stosowanych preparatów należą: 5-fluorouracyl, imikwimod, diklofenak, mebutonian ingenolu oraz retinoidy I i III generacji (retinol, adapalen, tazaroten). Prowadzone są ponadto badania w kierunku wprowadzenia do farmakoterapii nowych preparatów, takich jak nikotynamid, rezikwimod, piroksykam, dobesylan potasu oraz oleożele zawierające triterpeny (kwas betulinowy, betulina). W ostatnim czasie bada się również wpływ kwasu acetylosalicylowego oraz celekoksybu na zapobieganie AK. AbStrActActinic keratosis (AK) is a disease characterized by hyperkeratotic lesions on skin damaged by ultraviolet. radiation. These lesions may progress to squamous cell or basal cell carcinoma. Currently pharmacotherapy and different surgical procedures are used in AK therapy. The most common treatment options are 5-fluorouracil, imiquimod, diclofenac, ingenol mebutate, and first and third generation retinoids (retinol, adapalene, tazarotene). Furthermore, research is being carried out in order to test new medications including nicotinamide, resiquimod, piroxicam, potassium dobesilate and oleogel based on a triterpene extract (betulin, betulinic acid). Recently, the preventive effect of acetylsalicylic acid and celecoxib has also been investigated. Farmakologiczne możliwości leczenia rogowacenia słonecznego
The possibilities of using botulinum toxin beyond the dermatology · Botulinum toxin which is a neurotoxin produced by the bacteria Clostridium botulinum, is one of the most active and best-known biological toxins. Its mechanism of action is associated with proteolysis of specific proteins and prevention of release acetylocholine at presynaptic terminals in neuromuscular junctions. Botulinum toxin is mainly used in aesthetic medicine for reduction of wrinkles and in excessive sweating. Recently, it has been also used beyond the dermatology e.g. in the treatment of migraines, dystonia, bruxism or overactive bladder. Moreover, its beneficial effects on reducing depression and weight loss in obese people are currently investigated in observation and clinical trials.
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