PurposeTotal quality management is a valuable approach to continuously improve the quality of organizations; however, scholars debate its applicability to services, which require specific best practices that are different from those related to manufacturing. Moreover, digitization is pervading all kinds of services, but little has been written about total quality service practices in digital-based companies. For this purpose, the authors provide a holistic model of total quality service that reflects the peculiarities of such companies, guided by the question: how do total quality service practices change in digital-based service organizations?Design/methodology/approachThe authors conduct an illustrative case study on Healthware Group, a global integrated digital health organization, to evaluate theoretical assumptions about total quality service practices in the digital environment.FindingsThe findings allow to validate the model provided. In addition, the study enables them to observe the changes the authors are witnessing in service provision in the digital era and the consequent transformation of best practices. To be accurate, the authors cannot refer to a full transformation in digital-based companies but rather to the enrichment and extension of TQS practices. The best illustration of these conclusions has been summarized in a set of propositions corresponding to seven of the key levers of a TQS model.Originality/valueThe paper represents the first attempt to discuss the relationship between total quality service and digitalization, offering a set of propositions for academics and insights for practitioners. The model can be used as a tool to visualize the different levers that successful implementation of TQS in digital-based services companies can rely on.

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PurposeThe paper faces artificial intelligence issues in the venture creation process, exploring how artificial intelligence solutions intervene and forge the venture creation process. Drawing on the most recent literature on artificial intelligence and entrepreneurship, the authors propose a set of theoretical propositions.Design/methodology/approachThe authors adopt a multiple case approach to assess propositions and analyse 4 case studies from which the authors provide (1) more detailed observation about entrepreneurial process phases influenced by artificial intelligence solutions and (2) more details about mechanics enabled by artificial intelligence.FindingsThe analysis demonstrates artificial intelligence contributes alongside the entrepreneurial process, enabling mechanisms that reduce costs or resources, generate new organizational processes but simultaneously expand the network needed for venture creation.Originality/valueThe paper adopts a deductive approach analyzing the contribution of AI-based startup offerings in changing the entrepreneurial process. Thus, the paper provides a practical view of the potentiality of artificial intelligence in enabling entrepreneurial processes through the analysis of compelling propositions and the technological ability of artificial intelligence solutions.

Female, but not male, mice with haploinsufficiency for the proautophagic Ambra1 gene show an autistic-like phenotype associated with hippocampal circuits dysfunctions which include loss of parvalbuminergic interneurons (PV-IN), decrease in the inhibition/excitation ratio, and abundance of immature dendritic spines on CA1 pyramidal neurons. Given the paucity of data relating to female autism, we exploit the Ambra1+/− female model to investigate whether rectifying the inhibitory input onto hippocampal principal neurons (PN) rescues their ASD-like phenotype at both the systems and circuits level. Moreover, being the autistic phenotype exclusively observed in the female mice, we control the effect of the mutation and treatment on hippocampal expression of estrogen receptors (ER). Here we show that excitatory DREADDs injected in PV_Cre Ambra1+/− females augment the inhibitory input onto CA1 principal neurons (PN), rescue their social and attentional impairments, and normalize dendritic spine abnormalities and ER expression in the hippocampus. By providing the first evidence that hippocampal excitability jointly controls autistic-like traits and ER in a model of female autism, our findings identify an autophagy deficiency-related mechanism of hippocampal neural and hormonal dysregulation which opens novel perspectives for treatments specifically designed for autistic females.

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