The Corona virus disease 2019 (COVID-19) health crisis has not spared any country in the world, from the most advanced to the poorest. COVID-19 pandemic has exposed much vulnerability in systems and societies. In all resource-constrained countries, the response has been very complicated. The pandemic had to be dealt with very quickly with limited health and economic resources to avoid the hecatomb already predicted for these countries. In Côte d'Ivoire in particular, health and government authorities worked with state or private structures with infrastructure and human resource capacities to develop a rapid and effective response plan. Several measures have been adopted to reduce the spread of COVID-19. As a result of all these strategies, the number of cases of infected persons has been gradually decreasing. This new situation has favored the revision of certain restrictive measures, in this case the closure of air borders, which have of course been eased under certain conditions. Travelers are required to have a paper attesting to their negativity in COVID-19 test. Thus, Pasteur Institute of Côte d'Ivoire (IPCI), the reference laboratory for carrying out COVID-19 tests, was responsible for supplying a certificate of analysis to travellers. The purpose of this article is to show the internal process developed and different strategies implemented by IPCI to establish and deliver this document in order to meet the demand in the context of a pandemic.