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SummaryWe report a proving of Pulsatilla 3x conducted during three months of 1978 with 52 volunteers in North West England.The study included a double blind cross-over administration of placebo or medicated tablets in a manner intended to provide control as well as test phases.Two important findings are reported. First, that the results obtained failed to give statistically significant evidence for the effects of Pulsatilla 3x. Second, that the reported effects clearly indicated a “trial response”. That is, a response to the process of the trial rather than to the agent being proved.The significance and implications of these findings are discussed.