I3C-NMR spectra o f several 9-acridanones w i t h d i f f e r e n t s u b s t i t u e n t s b o t h on t h e r i n g (R,, = CH3, OCH3, NH2, NICH312, NOZ) and a t t h e n i t r o g e n atom (R2 = H, CH C H CH -C H CZC-CH (CH2I2N(C2H5l2. CH=C=CH21 have been recorded. The s h i f t s are discussed as a f u n c t i o n o f t h e nature o f t h e s u b s t i t u e n t , t h e importance o f p e r i s t e r i c i n t e r a c t i o n s and t h e e l e c t r o n i c s t r u c t u r e o f t h e acridanone r i n g . There i s a good l i n e a r r e l a t i o nship between the t o t a l e l e c t r o n i c d e n s i t y and the chemical s h i f t s . 3' 3 2 5 ' 2 6,3'
In vitro antiamebic activity of selected acridine derivatives has been investigated against Naegleria and Acanthamoeba species. The most active compounds belong to the 9-thioacridanone and the 1,2,3,4-tetrahydro-9-thioacridanone series. In addition, some structure-activity relationships are proposed.
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