e333using PapilloCheck (Greiner Bio-One), which evaluates 24 different HPV genotypes (18 high-risk and 6 low risk).Results: Positivity were 38,37% and 72.1% for cervical cytology and penile lesion biopsies, respectively. Multiple infections account for 41,5% in cervical cytology, and 61.3% in penile lesion biopsies. Of 1311 found viruses in cervical cytilogy, 73,7% were high risk, and of 68 found viruses in penile lesion biopsies 42.6% were high risk.In cervical cytology, positivity (P < 0,0001) and high risk genotypes (P = 0,0087) increased with the degree of cell injury. Moreover, the seven most common genotypes in normal cervical cytology were 16Additionally, hyperkeratosis (P = 0.003), irregular acanthosis (P = 0.003), and papillomatosis (P = 0.037) were associated with HPV in penile lesion biopsies. On the other hand, parakeratosis (P = 0.046), koilocitotic atypia (P < 0.0001), hyperplasia (P = 0.024) and loss of basal polarity (P = 0.024) were more prevalent in multiple infections than in simple.Conclusion: There are differences in positivity, multiple infections, and high risk genotypes prevalence between cervical cytology and penile lesions. Also, proportion of positivity and high risk genotypes increase with degree of cell injury in cervical cytology. Some cellular/hystological changes are significantly associated with HPV and multiple infections in penile lesion biopsies. http://dx.