On a group level, there is a dose-response relationship between PISA and HbA1c in type 2 diabetics. This might be an indication of a causal relationship between type 2 diabetes and periodontitis.

The sympathetic innervation of the rat pineal gland was investigated, measuring the norepinephrine (NE) release by on-line in vivo microdialysis. NE was assayed using an HPLC method with precolumn derivatization and fluorescence detection. Its high sensitivity and reliability made it very suitable to monitor the low levels of NE in the dialysates (12.5 fmol during nighttime, 3 fmol during daytime). To increase NE levels, the monoamine reuptake inhibitor cocaine was added to Ringer's solution at concentrations of 10-6 and 10~M. This resulted in increases of neurotransmitter output of 167 and 219%, respectively, but did not change the qualitative and/or quantitative outcome of other experiments. Perfusion with 10 6 M tetrodotoxin for 1 h resulted in a decrease of the NE release by >80%, whereas perfusion with the cn 2-receptor antagonist yohimbine caused a twofold in-

No abstract

With the absence or loss of an ear due to a congenital disorder, trauma, or malignant disease, an auricular prosthesis can be provided. In some patients, surgical ear reconstruction is an option, but this may be difficult, especially in burn victims or after oncological resections followed by radiotherapy. Even when 3D technology is used to fabricate a mold, the esthetic results are often disappointing. [1][2][3] Therefore, in most situations, silicone auricular prostheses are provided.Auricular prostheses can be retained with skin adhesive or with extraoral implants. Although implant retention is generally preferred, the choice between adhesive and implants depends on technical and patient-related factors. 4,5 Skin adhesives have disadvantages. Placing the prosthesis in the correct position can be difficult, the adhesives can dissolve leading to loss of retention, the skin, especially after radiation therapy, can become irritated, and skin reactions can result from intolerance to components of the adhesive or the solvent. 5