The immune system protects our body against pathogens and other foreign substances by producing a kind of glycoprotein known as immunoglobulin or antibodies from plasma cells or B-cells. Surveys show that about one-third of all adults believe they have food allergies. About 4-8% percent of young children are diagnosed with food allergies, most of which are evident in the first years of life and are often outgrown. A food allergy is any adverse reaction to an otherwise harmless food or food component that involves the body's immune system. In others a word, a food allergy is an immune system response to a food that the body mistakenly believes is harmful. Components of a food that trigger the immune system are called food allergens. Cows' milk allergy appears to be among the more prevalent food allergies in infants. Eggs and peanuts are also common allergenic foods for infants, along with soybeans, tree nuts, fish, and wheat. Seafood allergies, especially to crustaceans (shrimp, crab, lobster) are also rather common among adults. The present review provides brief information about food allergy and allergic reactions, their types, symptoms and approaches for reduction.

Fungal infections have become a subject of great concern and the incidence of fungal infections is increasing, presenting an enormous challenge to healthcare professionals. Since most of the fungal infections are occurring over the skin, the treatment option of these infections always involves topical application. However, in topical delivery drug reaches into systemic circulation through different barriers of skin. Nevertheless, due to the low permeability, skin restricts the movement of many drugs. Hence, a delivery system is required, which deliver the medicament into the skin layers or through the skin and into the systemic circulation. Ethosomes or Soft malleable vesicles are the novel lipid vesicular carrier that offer improved skin permeability and efficient delivery due to their structure and composition. They contain high concentration of ethanol, which increases the fluidity of the skin. Therefore, in the present paper, we have explored the utility of ethosomal systems in the topical treatment of fungal infections. Structure, compositions types, mechanism and techniques of preparation of ethosome also discussed in the paper.

In present scenario selective serotonin reuptake inhibitors are the first-choice drug for depression, but as per study of American Psychiatric Association monoamine oxidase inhibitor may be used as an antidepressant when other antidepressant trial on patient have been failed. Selegiline is both MAO-A and MOA-B inhibitor (dose dependent). Present delivery system is an in situ gelling system based on the chitosan and β-glycrophosphate. β-Glycerophosphate is used in form of di sodium salt which is a weakly basic compound which is naturally found in the body. In situ gelling system was prepared by addition of β- glycerophosphate to chitosan polymer causes conversion of pH sensitive chitosan to temperature sensitive. Developed formulations were evaluated for mucoadhesive strength, gel strength, drug content, in vitro release which was found 17.0±1.0 seconds, 6.4±0.1, 229.3±1.0 cp, 1433.3±1.2 cp, 99.45±0.4 %, 35.7±0.6 seconds, 3035.78±0.46 dyne/cm2 respectively. Histopathological studies of treated nasal mucosa of sheep revealed that selected formulation batch have no toxic effect on mucosal layer and no significant change was observed in mucosal structure. In vivo study of prepared optimized in situ gel was found more efficacious compare to marketed oral tablet of selegiline.