Coronary heart disease is a cardiovascular disease that has the highest morbidity and mortality rates in the world's uncontagious disease groups. Based on a Sample Registration System survey, the mortality rate from coronary heart disease amounted to 12.9% of all deaths. One of the causes of coronary heart disease is atherosclerosis. Atherosclerosis is a condition in which there is a process of forming plaques in the lumen of the arterial blood vessels. Atherosclerosis can occur due to an abnormal increase in cholesterol levels, resulting in a pathological accumulation in the walls of blood vessels and the formation of plaque obstruction. The plaque can narrow the lumen of the arteries and reduce blood flow to the heart muscle and then it may result in the onset of coronary heart disease. Cholesterol-lowering drugs are often used in atherosclerosis therapy. Tomato (Solanum lycopersicumshot) is a type of horticultural plants that contain many compounds that are useful for the body such as solanin alkaloids, saponins, folic acid, malic acid, citric acid, bioflavonoids including Lycopenes, and ß-carotene, proteins , fats, vitamins, minerals, and histamine.One of the most compound ingredients found in tomatoes is lycopene. Lycopene in tomatoes serves to ward off free radicals, as anti-platelet, and inhibit atherosclerosis so that it is beneficial in the prevention of coronary heart disease.

Penyakit kulit akibat infeksi jamur atau dermatofitosis ditemukan di segala lapisan masyarakat negara tropis dan lembab seperti Indonesia. Persebaran dermatofitosis dikaitkan dengan obesitas, diabetes melitus, kebersihan lingkungan yang buruk, kebiasaan menggunakan pakaian ketat dan lembab. Trycophyton rubrum menjadi jamur penginfeksi utama. Dermatofitosis dengan pengobatan lambat menyebabkan hiperkeratosis, hipergranulosis atau hipogranulosis pada epidermis. Farmakoterapi utama dermatofitosis meliputi mikonazol, bifonazol, flukonazol, ketokonazol, griseofulvin, terbinafin dan intrakonazol. Di antara obat-obat tersebut hanya intrakonazol yang bersifat fungisidal namun kurang diminati karena harganya cukup mahal, sedangkan obat yang lain bersifat fungistatik sehingga sering menyebabkan kekambuhan. Bawang putih menjadi suatu bahan alami yang dikategorikan sebagai komposisi obat herbal yang mengandung kurang lebih 33 komponen sulfur, enzim-enzim, 17 asam amino dan mineral, seperti selenium yang memiliki kekhasan bau dan berkhasiat sebagai obat antidiabetes, antihipertensi, antikolesterol, antiatherosklerosis, anti-oksidan, antikanker, antiagregasi sel platelet, antivirus, pemacu fibrinolisis dan antimikroba. Kandungan alliin bawang putih yang diremas akan teroksidasi menjadi allisin yang selanjutnya menjadi deoksi-alliin, dialyl disulfida (DADS) dan diallyl trisulfida (DATS), suatu senyawa antimikroba.