ISOX-DUAL is a dual inhibitor of CBP/p300 (IC50 = 0.65 M) and BRD4 (IC50 = 1.5 M) bromodomains, and a useful chemical probe for epigenetic research. Aspects of the published...
A cheap, conventional, sealed heating reactor proved to be a useful alternative to a microwave reactor in the synthesis of a >20-member MIDA boronate library (MIDA = N-methyliminodiacetic acid). Reaction times were 10 min and work-ups were minimal, saving on energy and solvent usage.
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