Introduction of radiolabeled epidermal growth factor (125I-EGF) by gavage or sublingual confinement resulted in a time-dependent uptake and systemic organ dissemination in the adult rat. Intact EGF was recovered primarily from the tongue, parotid, and sublingual/submandibular glands after administration by sublingual lozenge, whereas gastrointestinal administration resulted in 125I-EGF recovery primarily from plasma, stomach, and lung. Recovered radiolabeled EGF retained the ability to bind to the EGF receptor. Sialoadenectomy caused an increase in 125I-EGF in most tissues by both routes of administration. Thus, in the adult rat, at least two pathways exist for the uptake and distribution for salivary gland-derived EGF present in saliva. With further analyses, sublingual absorbance of EGF may therefore provide a potential delivery route for therapeutic use of growth factor, which avoids the hepatic destruction of EGF after oral administration.

A growing number of older Americans use a computer at home, and half of seniors who own computers also own modems that can connect them to online services; 25% of seniors with computers communicate with online services. Over 70% of online seniors use their computers every day. The dental office can interactively communicate one-on-one with current and prospective patients using an electronic mail newsletter, a Web page newsletter, an "Ask the Dentist" online service, or by making dental appointments online. Dental practitioners can take advantage of this online revolution and promote oral health for seniors using these technologies.