Methods: In this retrospective study, all undifferentiated malignant tumours and tumours with evidence of squamous differentiation from the head, neck and thorax seen between 01 January 2005 and 31 December 2016 were included. Nuclear protein in testis immunohistochemical staining was performed on all specimens. The stain was regarded as positive if speckled nuclear staining was observed in more than 50% of the tumour cells.Results: In total, 498 cases were investigated, of which 424 (85.1%) belonged to male patients. The mean age of the patients was 58.6 years. Only one positive case, a 30-year-old woman with a lung mass and lymph node metastases, was identified. Conclusion:Our findings confirmed the rarity of NC. Additional research in other provinces and the private sector is recommended to provide a comprehensive patient profile of NC in South Africa.