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Introduction: Patients with Pulmonary Hypertension (PH) have a severely impaired health-related quality of life (HRQoL). The emPHasis-10, a disease-specific HRQoL instrument for PH, has recently been developed and validated. The aim of this study was to assess the reliability and validity of the translated version of emPHasis-10 in the Italian language. Materials and Methods: The Italian version of the emPHasis-10 scale was sent by post to a group of 100 PH Italian patients recruited from the Associazione Malati di Ipertensione Polmonare (AMIP). Together with the emPHasis-10 two HRQoL validated scales were also sent: the Medical Outcomes Study 36-item Short Form (SF-36) and the Nottingham Health Profile (NHP). A written Informed Consent was sent with the questionnaires for explicit approval. 70 patients completed the three questionnaires in two occasions seven days apart, the first at T0 and the second at T1, and sent back by post with the signed informed consent. Statistical analysis was performed with the statistical software SPSS version 24. Results: Data showed that the scale has an excellent internal consistency (Cronbach’s Alpha> 0.9) comparable with the values of the original version, and a significant reproducibility (p <0.01) evaluated by comparing the T0 and T1 compilations. The scale correlated with the SF-36 and NHP scales demonstrating a good convergent validity. Discussion: The Italian version of the emPHasis-10 has been shown to be valid and reliable in the Italian population and can be recommended for use in clinical practice.