MPM patients are good candidates for CDKN2A mutational screening. These patients and some of their siblings should be included in a program of specific follow-up with total body photography and digital dermoscopy, which will result in the early detection of melanoma in this subset of high-risk patients and improve phenotypic characterization.

All cases of MM diagnosed in 23 Hospitals in Catalonia, from 2000 to 2007 were recorded and its incidence calculated and adjusted for the European standard population through the direct method. The age standardized rate varied from 6.74 in 2000 to 8.64 in 2007 for all melanomas and from 4.79 to 5.80 for invasive MMs, the Breslow thickness being stable during the period. The increase in invasive melanoma incidence in the elderly was remarkable, the crude rate increasing from 11.04 (2000) to 15.49 (2007) in the 60–64 yr population, while remaining more stable from 3.97 in 2000 to 4.55 in 2007 for the age range of 30–34 ys or with a tendency to decrease from 5.1 in 2000 to 2.5 in 2007 for age range of 25–29 yr, age ranges much more affected by immigration. Despite the large immigrant population (nearly one million immigrants that arrived in Catalonia during the study period from countries with a low melanoma incidence), melanoma incidence in our region has risen considerably and this trend will likely persist in the near future.

H. Animal type melanoma: a report of a case with balloon-cell change and sentinel lymph node metastasis.RAR-gamma. The special pharmacological properties of adapalene may explain why, when compared with tretinoin, it has an improved therapeutic ratio due to its better tolerance. 10 In our case, and being a localized form, we chose topical adapalene with the aim of achieving a good clinical response as well as minimizing side effects. The lesions were successfully treated with a 2-month course of 0.1% topical adapalene gel in occlusion applied at night only. At the end of this treatment, we observed clearance of crusts and papules with no significant irritation.In conclusion, adapalene is an option when considering an alternative treatment in localized forms of DD. It modules keratinocyte differentiation and has a more specific molecular pharmacological profile than tretinoin, resulting in high efficacy and less irritation.

Background Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM). Methods In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded. Results Although for the global period LM/LMM represented only 8.4% of cases, an increasing trend in this percentage was observed throughout the study period (from 6.9% [27 cases] in 2000 to 13.1% [94 cases] in 2007). Also, an increasing incidence of LM/LMM was observed, especially in chronically sun‐exposed areas (85.5% involving the head and neck region). During the 8 years of the registry, the mean Breslow thickness of LMM remained stable. However, the increase in the number of LM (in situ) cases was significantly higher than the increase of the invasive ones. Conclusions An important observation from this data is that aging of population and current sun exposure patterns could keep increasing the incidence of LM/LMM, which may become an important public healthcare problem, over the other histological subtypes. In order to establish primary or secondary preventive measures to the LM/LMM risk‐population, it is imperative to highlight the importance of chronic sun damage as a melanoma risk factor, and not only sunburn, most commonly addressed in melanoma prevention campaigns.