The domestic and care sector continues to display some problematic aspects due to its complexity, especially in terms of regulation. Italy represents a unique and peculiar case, where domestic and care work remains firmly under the purview of family management, and the work itself is entrusted mainly to immigrant workers. This paper aims to investigate, through in-depth interviews with representatives of both unions and employers’ associations, how the key actors involved in regulating domestic and care work intervene, understanding what kind of measures they take and what systems of relations/exchange exist among the different players involved in this process. The research sought to map strategies at a more macro level. While some of the actions undertaken by the social partners seem promising, there is still a lack of full responsibility for care at the public level, with marked asymmetries with respect to both services provided and working conditions.