A bstract Background Early loss of anterior primary teeth occurs mainly due to dental caries and trauma and may cause functional changes and negatively impact children's quality of life and social interaction. Aim and objective This article reports two cases in which pediatric patients with different dental losses were rehabilitated with esthetic functional fixed space maintainers with tube-bar system. Cases description In the first case, a 3-year-old boy with a missing upper central incisor due to dental trauma was rehabilitated with an esthetic functional fixed space maintainer with tube-bar system. In the second case, a 5-year-old boy lost three upper incisors, also due to dental trauma. He was likewise rehabilitated with an esthetic functional fixed space maintainer with tube-bar system. Conclusion The rehabilitation of early losses of anterior primary teeth by fixed esthetic functional space maintainers with tube-bar system proved to be a favorable treatment option regardless of the age of the patient or the number of missing teeth. Clinical significance Early loss of anterior primary teeth may have a major impact on the pediatric patient and is still a challenge in clinical practice. This article presents an effective and inexpensive alternative to this clinical situation. How to cite this article Volpato LER, Crivelli ASB, Oliveira ETRT, et al. Rehabilitation with Esthetic Functional Fixed Space Maintainer: A Report of Two Cases. Int J Clin Pediatr Dent 2021;14(2):315–318.