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We investigate the ground deformation and source geometry of the 2016 Amatrice earthquake (Central Italy) by exploiting ALOS2 and Sentinel‐1 coseismic differential interferometric synthetic aperture radar (DInSAR) measurements. They reveal two NNW‐SSE striking surface deformation lobes, which could be the effect of two distinct faults or the rupture propagation of a single fault. We examine both cases through a single and a double dislocation planar source. Subsequently, we extend our analysis by applying a 3‐D finite elements approach jointly exploiting DInSAR measurements and an independent, structurally constrained, 3‐D fault model. This model is based on a double fault system including the two northern Gorzano and Redentore‐Vettoretto faults (NGF and RVF) which merge into a single WSW dipping fault surface at the hypocentral depth (8 km). The retrieved best fit coseismic surface deformation pattern well supports the exploited structural model. The maximum displacements occur at 5–7 km depth, reaching 90 cm on the RVF footwall and 80 cm on the NGF hanging wall. The von Mises stress field confirms the retrieved seismogenic scenario.

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PURPOSE:We present a case-control study of seven polymorphisms of six genes involved in homocysteine/folate pathway as risk factors for Down syndrome. Gene-gene/allele-allele interactions, haplotype analysis and the association with age at conception were also evaluated. METHODS: We investigated 94 Down syndrome-mothers and 264 control-women from Campania, Italy. RESULTS: Increased risk of Down syndrome was associated with the methylenetetrahydrofolate reductase (MTHFR) 1298C allele (OR 1.46; 95% CI 1.02-2.10), the MTHFR 1298CC genotype (OR 2.29; 95% CI 1.06 -4.96), the reduced-folate-carrier1 (RFC1) 80G allele (1.48; 95% CI 1.05-2.10) and the RFC1 80 GG genotype (OR 2.05; 95% CI 1.03-4.07). Significant associations were found between maternal age at conception Ն34 years and either the MTHFR 1298C or the RFC 180G alleles. Positive interactions were found for the following genotype-pairs: MTHFR 677TT and 1298CC/CA, 1298CC/CA and RFC1 80 GG/GA, RFC1 80 GG and methylenetetrahydrofolate-dehydrogenase 1958 AA. The 677-1298 T-C haplotype at the MTHFR locus was also a risk factor for Down syndrome (P ϭ 0.0022). The methionine-synthase-reductase A66G, the methionine-synthase A2756G and the cystathionine-beta-synthase 844ins68 polymorphisms were not associated with increased risk of Down syndrome. CONCLUSION: These results point to a role of maternal polymorphisms of homocysteine/folate pathway as risk factors for Down syndrome. Genet Med 2006:8(7):409-416.

We present an overview of the Differential SAR Interferometry algorithm referred to as Small BAseline Subset (SBAS) technique, that allows us to detect surface deformation and to analyze their space-time characteristics. Following the description of the main theoretical aspects of the algorithm, we present several results obtained by applying the SBAS approach in selected case studies relevant to phenomena affecting volcanic areas (Campi Flegrei caldera and Somma-Vesuvio complex, Italy), aquifers (Santa Clara area within the San Francisco bay, California) and landslides (Maratea Valley, Italy). The overall analysis is carried out by using multilook DInSAR interferograms with a spatial resolution of the order of 100 · 100 m, computed from SAR data acquired by the ERS-1 and ERS-2 sensors. In particular, we highlight the peculiarities of the SBAS technique and its surface deformation retrieval capability for what concerns both large-scale deformation phenomena and more localized displacement effects.