The prolapse of pelvic organs (POP) is a prevalent disease in the elderly women with a significant impact on quality of life. Symptomatic POP requires treatment, but these women most often have other medical comorbidities that limit the therapeutic possibilities.In addition, significant rates of recurrence and complications following reconstructive surgery demand simpler and faster surgeries. For this reason obliterative surgeries such as Le Fort colpocleisis returned to be appointed and new studies have demonstrated its correct indication and success rates. This article describes results of a cases series of patients undergoing colpocleisis surgery for treating of advanced pelvic organ prolapse (POP) and compare them with some literature data. Citation: Marchesini AC, Antunes JA, Gusmão LC, et al. Colpocleisis surgery in the treatment of pelvic organ prolapse in elderly women. Citation: Marchesini AC, Antunes JA, Gusmão LC, et al. Colpocleisis surgery in the treatment of pelvic organ prolapse in elderly women.