Abstract. The purpose of this study was to determine the effect of permeation enhancers on the transbuccal delivery of 5-fluorouracil (FU). The effect of permeation enhancers on in vitro buccal permeability was assessed using sodium deoxycholate (SDC), sodium dodecyl sulphate (SDS), sodium tauroglycocholate (STGC), and oleic acid and their concentrations for absorption enhancement were optimized. STGC appeared to be most effective for enhancing the buccal permeation of FU than the other enhancers. These enhancements by STGC were statistically significant (p<0.05) compared to control. The order of permeation enhancement was STGC > SDS > SDC > oleic acid. Histological investigations were performed on buccal mucosa and indicated no major morphological changes. The enhancing effect of STGC on the buccal absorption of FU was evaluated from the mucoadhesive gels in rabbits. The absolute bioavailability of FU from mucoadhesive gels containing STGC increased 1.6-fold as compared to the gels containing no permeation enhancer. The mean residence time and mean absorption time considerably increased following administration of gel containing penetration enhancer compared with the gel without penetration enhancer.
Premarital Health Counseling (PMHC) is emerging as a growing trend worldwide. The couples are provided with accurate and unbiased information and assistance, who are planning to get marry with the aim of screening, educating, and counseling about nutritional disorders, communicable diseases, medical conditions, hereditary/genetic disorders, and guiding for a healthy pregnancy. Premarital screening and adequate counseling are essential for changing attitudes toward consanguineous marriage particularly in places where consanguineous and "tribal" marriages are common, resulting in a high incidence of genetic disorders. Although making PMHC obligatory in India may appear to be a very exciting and promising proposal, its implementation still has various ethical issues and other barriers that need to be addressed.
Background: Antenatal care (ANC) provides an important opportunity to improve maternal understanding about pregnancy, childbirth, and care of the newborn. Adequate and quality ANC can help ensure a favourable pregnancy outcome, but the coverage of ANC in India remains inadequate. The present study was conducted with an objective to assess ante natal counselling services at health centers in Chandigarh Tricity.Methods: The cross-sectional study was conducted in the Chandigarh Tricity during April 2012 to September 2013. Stratified multistage sampling technique was used to select health centers in tricity. A total of 345 pregnant women in second and third Trimester were interviewed with the help of pre-designed, structured and pre-tested questionnaire after taking their written informed consent. It was supplemented by observation of ante natal sessions. Data was entered and analyzed using SPSS version 19.Results: Nearly one-fourth (28.1%) participants received counselling regarding diet and rest. Only 26 (07.5%) participants were explained about danger signs during pregnancy. Significant difference was found between counseling given regarding ‘diet and rest’ with respect to city (p=0.03) and health centers (p=0.00). Significant difference was found between counselling for ‘family planning’ with respect to city (p=0.01) and health centers (p=0.00).Conclusions: Findings from our study indicate low level of counselling on various components of ANC. Thus, strategies under National Health Mission to improve quality of antenatal communication as well as maternal understanding should be strengthened.
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