In this review we hope to explain regarding nanoparticles (NPs), Nanoparticles are very small materials that range from 1 to 100 nm size. And the subclasses of nanoparticles are mentioned. Nanomaterials are formulated by nanoparticles. Research on nanomaterials is used to improve in material technology and synthesis gained the support. Nanomaterials are gradually becoming popularized and starting to arise as commodities. Nanotechnology refers to a set of scientific disciplines and designing where peculiarities that occur at aspects in the nanometre scale are used in the plan, characterization, formulation and use of materials, structures gadgets and system. Here application of nanomaterial and nanotechnology is explained. The use of nanomaterials in the production of biosensors for detection of pathogens, formulation of nanomaterial-based biosensors for detection of antibiotics, Nanomedicines and the application of nanotechnology in food business Etc were discussed. Hazards and risk of nanomaterials are studied under nanotoxicology. Nanotechnology is ab arising science as would be considered normal to have quick areas of strength for improvements. It is anticipated to contribute altogether to financial development and occupation creation in the next few decades.

For the treatment of various infections, a variety of antimicrobial drugs are formulated. Nevertheless, many bacterial infections now exhibit antibiotic resistance due to the widespread utilization antibiotics. Methicillin-resistant among the most dangerous multidrug-resistant bacteria is Staphylococcus aureus (MRSA). Vancomycin became a viable therapy option due to MRSA resistance to methicillin medicines. One of the well-informed antibacterial compounds with wideband antibacterial activity is silver nanoparticles (AgNPs). AgNPs are thus suitable candidates for usage in conjunction alongside vancomycin to increase its antibacterial effect. The goal of the present research work is to boost the antibacterial potency of the glycopeptide antibiotic vancomycin towards Gram-positive (Staphylococcus aureus) but also Gram-negative (Escherichia coli) bacteria. The chemical reduction approach is used to create a colloidal solution of silver nanoparticles utilizing silver nitrate as a precursor in the environment of the ionic surfactant trisodium citrate that serves as covering including reducing reagent. Vancomycin was used to functionalize the synthesized nanoparticles and create the nanodrug complex (Van@AgNPs). The synergistic antibacterial potential of silver nanoparticles coated with vancomycin on both test pathogens was investigated using the agar well diffusion technique. The antibacterial potency for both classes of bacteria has significantly increased, according to the well diffusion test. It has been noted that this improvement is synergistic instead of additive.

Centella asiatica is mostly used in Chinese & Ayurvedic, Unani medicine as a Memory Enhancer, Nervous system disorders, and Topical Skin Disease treatments. Triterpenoids, Saponins are important chemical constituents believed to exert these pharmacological actions. Apart from this it’s also used in diarrhoea, fever, amenorrhea, reliving anxiety and cognitive effects’ asiatica or Gotu kola is often confused with kola nut which does not contains any CNS stimulants like caffein and do not show any stimulant effect. For hundreds of decades before it was used in ayurvedic system of medicine, which is recorded in ‘Sushruta Samhita’ an ancient ayurvedic medical manuscript. It’s also used by Indonesian and Javanese; Chinese ancient peoples know over 2000 years ago. This article focuses on the Phytochemistry, Traditional uses, Pharmacological effects, Toxicology of Centella asiatica.