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Cholelithiasis in female is increasing rampantly among obese [1,2], hyperlipidemic and hypo functioning thyroid women who undergone tube ligation or hysterectomy may be synergized by increasing toxic non nutrients in diet and changed life style, Common surgical preference Cholecystectomy and Choledochotomy though relieve the agonizing pain but alter digestion permanently which predisposes for the continuance of the presentation like heaviness in the abdomen, heart burn, eructation, lethargy, bowel irregularity in spite of dietary restriction.Placebo based control study to evaluate a herb mineral composit in 216 cases affirm its worth in relieving clinical presentation and USG confirmation in majority cases with grade I clinical response while control group shows only transient symptomatic relief. 3 years post therapy follow up and dietary restriction with maintenance dose of 1 pill daily, none had any bowel irregularity or any evident cholelithiasis or hyperlipidemia.

Enzymes have wide applications in detergent industry from early 1900’s. Mostly, clothes are soiled by protein based grime. Most of the detergents have either amylase / protease. Various sources were scrutinized for potent protease activity and Betel leaves were selected, the enzyme was then isolated, purified to homogeneity by ammonium sulphate precipitation, DEAE-Cellulose and gel permeation chromatographic techniques. The enzyme was monomeric in nature with a molecular mass of 38kDa as determined by native PAGE and SDS-PAGE. The enzyme shows maximum activity at 60oC and pH 4.0. The Km and Vmax of the enzyme were 4x10-3M and 54µmol/min/mg respectively. The enzyme was categorically inhibited by PCMB and iodo-acetamide suggesting it to have papain like nature. The stability of the enzyme is assessed over the stretch of alkaline pH and temperature. This evaluation validates the stability of the enzyme and its use in detergent formulations. It was evident that after adding the enzyme preparation the stains (tea, chocolate, blood) were removed much better than that of the controls, which affirms that papain like enzyme from betel leaves, enhances detergent activity.

Hypothyroidism is increasing worldwide and female predominate male i.e.-1 out of 50 female and 1 out of 1000 male. TSH (thyroid stimulating Hormone, a secretion of pituitary gland) level is adjudged as an index of diagnosis of thyroid function. Hypothyroid status needs L thyroxin supplementation but its variable schedule poses metabolic dysfunction Objective of Study: To adjudge clinical effect of early morning fixed time intake of L thyroxin verses unscheduled administration in bioregulation of TSH level and metabolic process Material & Methods:

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