In a comparative aspect and dynamics in the conditions of urbanized territories, the structure of invasive pathology and the effectiveness of anti-invasive measures were studied. It was established that the epizootic situation is controlled by parasitological, microscopic and hematological studies for 12 invasions. It was determined that from the period from 2020 to 2022, there is a negative trend in the defeat of farm animals and unproductive domestic animals with invasive diseases (from 25% in 2020 to 0.57% in 2022). At the same time, nematodes play a leading role in the invasive pathology of animals - from 60.5% of those affected in small cattle to 0.6% in dogs. In our opinion, the negative dynamics is associated with the optimization of the system of anti-epizootic measures in a metropolis, aimed at the source of the pathogen, the mechanism of its transmission and susceptible animals. It was stipulated that in order to control and determine the effectiveness of the implementation of an optimized scientifically based system of antiparasitic measures, continuous study and assessment of the epizootic situation among cattle are required; laboratory screening of animals and habitat.