In adult male Wistar rats {Rattus norvegicus albinus) gingival irritation provided by means of wire silk ligatures around the cervix of first left lower molars, for a duration of 77 days, caused gingival inflammatory changes. In the rats receiving also daily one i.p. injection of sodium 5,5diphenylhydantoinate (phenytoin)., during 70 days, there was no macroscopical change of the gingiva of non-ligated first right lower molars. However, in the first left lower molars, the association of silk ligature-plus-phenytoin administration elicited gingival overgrowth. The rat was seen as a satisfactory animal model for studies of phenytoin-induced gingival changes.

The systemic administration of steroid hormone (0.400 mg of Dexamethasone every 2 days), during a 28-day period in marmosets (Callithrix jacchus) produced modifications in the evolution of the experimental periodontal traumatism. The observed changes were osteoporosis and reduction of the periodontal fibers in quantity as well as a reduction of repair process, when compared to the control group that only received the action of the trauma from occlusion.

orientação nos p a ~ sos iniciais da minha carreira universitária;.•. Aos colegas do Curso de Pós-Graduação: Walter

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