Many free radicals are generates in the human body due to metabolic processes and in order to counteract the harmful effects of these antioxidants, human body has a complex system of natural enzymatic and non-enzymatic antioxidant defenses or mechanisms. These free radicals are mainly responsible for generation of different types of diseases and disorders. Hence protection of body against free radical is important and which can also be done by taking diet with maximum antioxidants. Naturally occurring antioxidant are very important in preventing body from various free radicals. Many medicinal plants and their extracts have been reported for potential anti-oxidant activity. Curcuma amada Roxb (Mango Ginger) is the most important genera come under the Zingiberaceae family. Chemically it has reported for the presence of wide range of phytoconstituents which include the flavonoids, terpenoids, tannins steroids, alkaloids, glycosides and essential oils. Due to presence of wide variety of phytoconstituents plant has very well traditional value reported for pharmacological significance for a variety of ailments. It effectively treats skin allergies, stomach problems, and high blood cholesterol and has been reported for antioxidant properties. In the present review work various research articles published on antioxidant activity of Mango Ginger Have been collected from various journal site and databases and explored systematically

Cardiovascular (CVS) drugs are medications whose primary effects are experienced by the heart and blood vessels to treat cardiovascular disorders such as coronary artery disease, arrhythmias, high blood-pressure, heart failure and stroke. Evaluation of drug-likeness is a qualitative research approach in drug design that examines the drug-like properties of any chemical compound used as a lead in terms of factors such as oral bioavailability. These ADME parameters can be used widely in drug discovery to optimize the properties needed to convert lead candidates into safe and effective drugs for human use. An approach to estimate the passive gastrointestinal (GI) absorption and blood-brain barrier (BBB) access of drugs is the BOILED-Egg model from Swiss-ADME. In the current study, we virtually screened fifty-five bioactive CVS agents, which twenty-three were newly marketed agents and thirty-two were conventional agents. PubChem database for canonical smile collection, Molsoft server for physicochemical properties and drug-likeness screening, Schrodinger's software for ADME parameters, Microsoft Excel software for Heat-Map analysis, Swiss-ADME database for construction of BOILED-Egg model were utilized. The study results revealed that out of fifty-five screened bioactive drugs, forty-six drugs obeyed Lipinski's rule of five (RO5) and forty-five drugs obeyed Jorgensen's rule of three (RO3), were within recommended ranges of physicochemical and pharmacokinetic properties. Few of the compounds found in the Egg-yolk and Egg-white were predicted to pass the BBB and GI, respectively. It can be concluded that maximum of the screened bioactive drugs are proved to be potent drug candidates with good membrane permeability and oral bioavailability.