Objective: To define optic neuritis associated with chikungunya virus (CHIKV) infection in a clinical setting. Methods: This observational case series includes 14 patients with clinical features of CHIKV infection and associated optic neuritis. Complete ophthalmic evaluations were performed, as well as other examinations, including Mantoux test, Widal test, blood profile, color vision, neuroimaging, visual fields, visual evoked potentials, VDRL test, and enzyme-linked immunosorbent assay for CHIKV-specific immunoglobulin. Relevant clinical findings of optic neuritis associated with seropositive CHIKV infection were recorded. Results: Nineteen eyes (in 14 patients) had optic nerve involvement. The mean ± SD patient age was 45.8±15.6 years. Eight eyes (42%) had papillitis, 4 eyes (21%) had

Tobacco consumption is the leading preventable cause of disease, disability, and premature death but little is known about its deleterious effect on the ocular health of workers handling tobacco. The goal of this study was to identify probable effects of occupational tobacco exposure among south Indian bidi- industry workers. This study included 310 females (mean age, 34.8 ± 10.9 years) actively involved in bidi-rolling presenting with eye symptoms to a tertiary eye care hospital. Results suggested that a wide spectrum of ocular complications exist among these workers. Common ocular symptoms were defective vision, dull- aching headache and eye irritation. The main ocular findings were papillary conjunctival hyperplasia, hyperpigmentation of ocular surface, punctate epithelial erosion or superficial punctate keratitis, cataract or pseudophakia and segmental optic atrophy. Abstaining from work, supplementation of Vitamin B complex rich in B 12 and appropriate surgical or medical management reversed visual loss due to corneal disease or cataract but was not effective in optic neuropathy.

Preparation and studies of ion exchangeable epoxy resins, stimuli responsive hydrogels, and polymer-dye conjugates have been accomplished through hydrazide based click reactions using polyacryloyl hydrazide (PAH) as the precursor. A convenient synthesis of PAH with quantitative functionality was achieved by treatment of polymethyl acrylate with hydrazine hydrate in the presence of tetra-n-butyl ammonium bromide. PAH was cured with bisphenol A diglycidyl ether (BADGE) at 60 °C to form transparent resins with superior mechanical properties (tensile strength = 2-40 MPa, Young's modulus = 3.3-1043 MPa, and ultimate elongation = 9-75%) compared to the conventional resins prepared using triethylene tetramine. The resins exhibited higher ion exchange capacities (1.2-6.3 mmol/g) compared to the commercial AHA ammonium-type (Tokuyama Co., Japan) membranes. An azo dye with aldehyde functionality was covalently attached to PAH through hydrazone linkage, and the dye labeled PAH exhibited colorimetric sensing ability for base and acids up to micromolar concentration. The swelling of the PAH based hydrogel varied in the range 4-450% depending on the pH and temperature of the medium. The hydrogels gradually released 30% of the original encapsulated dye in a period of 200 h. PAH-hydroxy naphthaldehyde conjugate released 75% of the original loading in ∼11 days at 37 °C and pH 5.0 through cleavage of the -CONHN═C- linkage. The study depicts the versatility of PAH as a precursor and inspires synthesis of a range of new materials based on PAH in the future.

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Background: Intradermal administration of QR678 Neo ® hair re-growth factor formulation has already proven its effectiveness and safety in treating androgenetic alopecia and female pattern hair loss.Aim: This study aims to evaluate effectiveness and safety of hair re-growth factor formulation at multiple centers for reduction of hair fall and regrowth of hair in androgenetic alopecia and female pattern hair loss. Materials and methods:An open-label, prospective, and interventional study was carried out at multiple centers of different countries. A total of 2428 patients with androgenetic alopecia and female pattern hair loss within the age range of 18-65 years were included in the study. Hair pull test, global photographic assessment, videomicroscopic assessment tests were performed at the beginning, after fourth and eighth sessions, and self-assessment through questionnaire related to satisfaction and side effects was carried out at beginning and at after eight session.Results: Hair pull test was positive in only 12% of the patients after eight sessions.Beneficial results were noted in the global assessment score (mean-6) after fourth session and eighth session (mean-8). Huge improvement was noted in terminal hair count, vellus hair count, and hair density after eighth sessions. Also, with self-assessment score, a higher satisfaction score was noted. On long-term follow-up as well, no side effects were noted. Conclusion:Intradermal administration of QR678 Neo ® is an innovative, efficacious, and safe technique for the treatment of androgenetic alopecia and female pattern hair loss.