Immunization is effective way to reduce morbidity and mortality of infectious diseases. However, there is only 59,2% early child in Indonesia is fully immunized. Health workers have an important role in that practice. Immunization status of children in Ciampea and Kalibata Early Childhood School has not known Their health worker�s role either. Therefore, this study was conducted to know the role of health worker in early childhood students in Ciampea and Kalibata Preschool. This study used a cross-sectional design. With quota as its sampling technique, there were 145 early child aged 12-59 months. multivariate. After multivariate analysis, the result of this study describes there is health worker advice is significantly associated with primary immunization with AOR 5,27 (95%CI: 1,05 � 26,32) dan p-value = 0,043. The mother who had to advise from health workers is 5,27 likely had fully immunized their children. Hence, health workers capacity should be increased to get more fully immunized early child.

BACKGROUND: Meningioma is the most common primary intracranial tumors in adults, accounts for 36% of total intracranial tumors. Obtaining the clinicopathological characteristics of patients with meningioma and investigating, the association between signaling pathways with disease progression could provide a basis for therapeutic development.AIM: This study aims to investigate the expression of transforming growth factor-β1 (TGF-β1), E-cadherin, and Ki-67 in meningiomas.MATERIALS AND METHODS: This study examined the expression levels of E-cadherin, Ki-67, and TGF-β1 with respect to the WHO grade in patients with meningioma. A total of 62 meningioma samples were analyzed. By the WHO criteria, 54 specimens were diagnosed as the WHO Grade 1, 6 as Grade 2, and 2 as Grade 3. Grade 1 was classified as low-grade meningioma, while Grade 2 and Grade 3 were classified as high-grade meningioma (HGM).RESULTS: In this study, the mean age diagnosis was 41.97 ± 9.79 years old, with female: male ratio of 8:1. There was no association between age, sex, and tumor location with the progression of meningioma. Immune-characterization revealed that HGM was associated with the higher number of Ki-67+ cells (p < 0.0001) and lower expression of TGF-β1 and E-cadherin (p < 0.001). The number of Ki-67+ cells was inversely correlated with TGF-β1 and E-cadherin (p < 0.05). TGF-β1 expression was positively correlated with E-cadherin expression (p < 0.0001).CONCLUSION: This study concluded that HGM was highly proliferative (high Ki-67+) and invasive (low E-cadherin), with dysregulated TGF-β1 signaling. In addition, younger age at diagnosis and high female: male ratio in our series suggests that Indonesian females might possess specific risk factors for having meningioma.