The aim of this study was to evaluate the prenatal and postnatal outcomes of fetuses with increased nuchal translucency thickness (NT) and normal karyotype. This study from 2011 to 2013 included 8640 pregnant woman attending the outpatient clinic for the first trimester screening. 245 fetuses with increased NT were submitted to karyotyping analysis, serial anomaly scans, echocardiography and postnatal clinical evaluation. The karyotyping was abnormal in 14.2 % of the cases and normal in 85.8 %. In the present study, 86.6 % of cases with normal karyotype had a normal prenatal and postnatal evaluation. Adverse pregnancy outcome such as spontaneous fetal loss, hydrops, structural abnormality and termination of pregnancy due to multiple anomaly occurred in 13.3 % of cases with normal karyotype. Studying singleton fetuses with an increased NT above the 95 th percentile and normal karyotype showed a percentage of 86.6 % intact survival.