Novel poly(vinyl alcohol) (PVA) and chitosan (CS) or 2-hydroxyethyl methacrylate (HEMA) and nanohydroxyapatite (nanoHAp) electrospinning-produced membranes were evaluated, in terms of their bioactivity under exposure to simulated body fluid (SBF). After soaking them in SBF for 5, 8 and 15 days, the scanning electron microscopy (SEM) images show the accumulation of calcium carbonate or calcium phosphate SBF on the surface of the nanohydroxyapatite (nanoHAp). This indicates that there might be an increased bioactivity on the surface of the nanoHAp prepared by this method.