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Although breast cancer treatments have made great strides in recent decades, there are still many recurrences. Late recurrence is one of the characteristics of breast cancer. Here, we present four cases of recurrence more than 10 years after the initial diagnosis. The time from diagnosis to recurrence was 13 to 20 years in our four cases, which were all estrogen receptor (ER)-positive, and one was also human epidermal growth factor receptor 2-positive. Long-term hormone therapy for 10 years is necessary to prevent late recurrence of breast cancer, but we need to know that late recurrence remains common. Risk factors for late recurrence include ER positivity, progesterone receptor positivity, and low Ki67. The most common sites of recurrence are the lungs/pleura and bones, which was also the case in our experience. It is no exaggeration to say that breast cancer is a chronic disease similar to hypertension and diabetes. This is because breast cancer is not completely cured by surgery alone and lasts for a long time, with patients requiring long-term hormone therapy. Moreover, it can recur even after 10 years or more.

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General Hospital Granular cell tumor of the colon is relatively rare. We encountered a case of multiple granular cell tumors of the cecum that were discovered because of early gastric cancer and were resected simultaneously by laparoscopy. A 47-year-old man was referred to our hospital with chief complaints of epigastric pain and indications of Ⅱ c lesions in the gastric antrum on upper gastrointestinal endoscopy. Computed tomography showed a tumor about 1 cm in size in the cecum, and lower gastrointestinal endoscopy showed two submucosal tumors at the same site, 12 and 10 mm in diameter. The patient was diagnosed with early gastric cancer and submucosal tumors of the cecum, and underwent laparoscopically assisted distal gastrectomy with ileocecal resection. Postoperative histopathological examination diagnosed multiple granular cell tumors of the cecum. Surgery was repeated on postoperative day 8 due to suture failure, but the subsequent course was favorable, and he was discharged in remission on hospital day 23. No standard treatment has been defined for granular cell tumors of the colon. The present case underwent ileocecal resection at the same time as a procedure for early gastric cancer, and we consider this as a valid surgical procedure in light of the fact that these multiple tumors were not diagnosed preoperatively. Key words：granular cell tumor of the colon，early gastric cancer，laparoscopic resection