Agroforestry adoption as a drought adaptation option has an omnibus of opportunities for smallholder farmers in semi-arid regions. This study assessed the severity and frequency of drought and the determinants of agroforestry adoption in Nakasongola District. The episodes were examined using the Standardised Precipitation Index (SPI) set at 3, 6 and 12 months timescales. A cross-sectional survey using semi-structured questionnaires, focus group discussions and key informants were adopted. A total of 200 farmers were randomly selected and studied. The adoption was determined using a binary logistic regression. The SPI results showed that the extreme drought years recorded were 1980, 1984, 1986, 1990, 1995, 1999 The average return period of severe droughts was 4 years. The levels of agroforestry uptake were higher (85%) between July and June drought period. Agrisilviculture, agrosilvopastoral, silvopastoral and apiculture were the most adopted agroforestry systems by the farmers. The household age, level of education and income were the major significant determinants of agroforestry adoption (p<0.05) in adaptation to drought by the smallholder farmers. The potential benefits of agroforestry adoption included the provision of food, fodder, erosion control and soil fertility enrichment, however, the farmers were mainly constrained by inadequate funds, shortage of tree planting stock, limited extension services and information on agroforestry production. Thus, carrying out massive awareness campaigns on agroforestry practices is more likely to increase the uptake.