Four-component condensation of benzil, aromatic aldehydes, primary amines and ammonium acetate catalyzed by zeolite HY and silica gel without any solvent under microwave irradiation leads to tetrasubstituted imidazoles in high yields and purity.

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This paper dedicated to Dr. Shahriyar Omidvar for his effective contribution in Iranian pharmaceutical industryA highly efficient and practical synthesis of C-terminal amidated peptides has been developed. According to this approach, amidation of the C-terminus of peptides was carried out using NH 4 Cl, alkylammonium chloride (RNH 3 Cl) and semicarbazide hydrochloride in the presence of TBTU as a coupling reagent and a tertiary amine as the base at room temperature in good to high yields. Some opioid peptides such as enkephalin derivatives were synthesized according to this novel method.