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2‐Oxoquazepam, 7‐chloro‐1‐(2,2,2‐trifluoroethyl)‐1,3‐dihydro‐5‐(2‐fluorophenyl)‐2H‐1,4‐benzo‐diazepine‐2‐one, is a benzodiazepine agonist. It has been shown to bind in vitro with a higher affinity to benzodiazepine type 1 receptors than to type 2 receptors. Here we report the synthesis of a trimethyltin precursor and demonstrate the feasibility of using it for radiolabelling acid‐ and base‐sensitive benzodiazepine structures such as 2‐oxoquzepam. Conversions of the electrophilic fluorine to [18F]‐2‐oxoquazepam on the order 20–25% were obtained.

Additional Data on Vitamin B]2a 335 with hydrobromic acid. The hydrogenation of apo-and isoapo-5-erythroidine yielded the same compound, octahydro-apo-/3-erythroidine. Oxidation of apo-/3-erythroidine gave formic acid.Interpretation of these reactions and degradation products of ß-erythroidine allows one to formulate tentative structures for these products. Rahway, N. J.

Vol. 68 mixed melting point with fluorenone-hydrazone prepared by the interaction of fluorenone and hydrazine was unchanged; hydrochloride, deep yellow crystals melting at 268= (dec.).Reaction of 9-Chlorofluorene with Piperidine.-Colorless needles were deposited from a solution of 0.5 g. of 9chlorofluorene in 5 cc. of piperidine kept at room temperature for a few hours. The product, 9-(N-piperidino)fluorene, was recrystallized from ethyl alcohol and melted at 99°.