The study on the growth responses of Oreochromis niloticus exposed to different concentrations of detergents powder was carried-out using a 30 day renewal bioassay in triplicates. A total of 360 Oreochromis niloticus fingerlings, with a mean bogy weight of 18.2 ± 3.02 g were used for the study. Ten fingerlings were stocked in each aquarium containing 10 litres of water and exposed to 0, 1. 5 and 9 ml concentrations of detergents. The DWG, PWG, SGR and SR (growth responses) of the test fish varied significantly between the fish groups exposed to different concentrations of detergent "A", "B" and "C" at p<0.05, having homogenous variances in each group (p>0.05). The DWG, SGR, SR and PWG of the test fish decreased with increase in the concentration of each detergent, with the highest growth reduction of 0.50 ± 0.05 g (DWG), 1.34 ± 0.11% (SGR), 46.67 ± 11.55% (SR) and 33.14 ± 2.21% (PWG) for detergent "A"; 0.41 ± 0.06 g (DWG), 0.50 ± 0.06% (SGR), 36.67 ± 5.77% (SR) and 28.96 ± 2.77% (PWG) for detergent "B"; 0.39 ± 0.01 g (DWG), 0.47 ± 0.02% (SGR), 30.00 ± 10.00% (SR) and 27.85 ± 0.77% (PWG) for detergent "C" observed at the