The main aim of the present work was to prepare TPGS stabilized D-α-Tocopherol, lemon oil, tween-80, and water nanoemulsion by low cost and highly effective sonication method. The prepared nanoemulsion showed good stability for 60days at variable temperature conditions i.e. 4, 25 and 37°C. The tolerance of the prepared nanoemulsion to salt (50mM-500mM) and pH (pH 2-pH 7.4) was also studied. The morphology and droplet size of pure and quinine loaded nanoemulsion was characterized with transmission electron microscopy. The prepared formulation was transparent and the obtained average particle size ranged between 25nm and 35nm. The nanoemulsion was found to be non toxic. The cell viability study of pure nanoemulsion carried out on Hep G2 cells revealed that the cell viability was 100%. The formulation further exhibited high quinine loading and release capacity with cumulative release up to 76±2% and 65±2% at pH 7.4 and pH 5.5 respectively. The interaction between quinine and vitamins (riboflavin, thiamine and biotin) was also carried out (aqueous medium). The study revealed that riboflavin had strong interaction with quinine and vitamins vis-à-vis thiamine and biotin.

Background: Type 1 diabetes mellitus (T1DM) mostly presents as diabetic ketoacidosis (DKA) and is a common pediatric endocrine emergency. There is dearth of literature on clinical profile of T1DM from North India. Objectives: 1. To identify the clinical profile of patients admitted with T1DM at a tertiary care hospital. 2. To assess the predictors of adverse outcome in patients with T1DM.

The word "yoga" is commonly used to refer specifically to Hatha yoga stretching postures or generally to Hatha yoga programs that also include certain relaxation,breathing and meditation practices. Such programs, however, represent only certain aspects of the comprehensive system that comprises the physical, psychological,philosophical, and spiritual components of yoga. In the generic sense, yoga means the practical aspect of a philosophy, — its methods and application. More specifically, it refers to the philosophical view of the world and the individual described in the Yoga Sutras of Patanjali and related texts.

Access to safe drinking water and a hygienic living environment are the basic necessities that encourages healthy living. However, the presence of various pollutants especially heavy toxic metal ions in...

In silico drug design can play a vital role in identifying promising drug candidates against COVID-19. Herein, we focused on the main protease of SARS-CoV-2 that plays crucial biological functions in the virus. We performed a ligand-based virtual screening followed by a docking screening for testing approved drugs and bioactive compounds listed in the DrugBank and ChEMBL databases. The top 8 docking results were advanced to all-atom MD simulations to study the relative stability of the protein-ligand interactions.Our results suggest several promising approved and bioactive inhibitors of SARS-CoV-2 Mpro.