River pollution in Indonesia is one of the biggest problems and tends to increase perpendicular to the rapidly developing population and human activities. As stated in Sustainable Development Goals (SDGs) number 6, clean water and sanitation are also becoming an international priority of sustainability. Therefore, understanding the interaction pattern between pollution and various human activities around the site can be a consideration for water environmental pollution mitigation policies. This study assesses the water quality of the Bango River segment, as a typical "urban river". The results indicated that the Bango River water quality was classified as "Slightly Polluted" (i.e., with a Pollution Index = 1.3802; Storet = -4). Urban and agricultural activities are significantly related to pH and ORP parameters in the Bango River (Pearson correlation p-value>0.05). These findings can become a reference for future appropriate mitigation policies to maintain water quality and minimize the negative impacts of human activities on river ecosystems.